Department of Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-331, Tehran, I.R. Iran.
Abstract
Class-Pi of glutathione s-transferases (GST-Pi) is the specific form of GSTs that are known to participate particularly in the mechanisms of resistance to drugs and carcinogens. This class of the enzyme is referred to as class-P or class-Pi or class π. The accepted terminology in this review article is class-Pi. In this article following a brief description of identified molecular forms of GSTs, we focus on GST-Pi. We review new findings about the structure and regulation of GST-Pi gene. Then, the role of GST-Pi in liver damage, oxidative stress, carcinogenesis and drug resistance are discussed. Also, the presence of common genetic polymorphism, hypermethylation in GST-Pi gene and the consequences GST-Pi knock out is regarded.
Kazemnejad, S., Rasmi, Y., Sharifi, R., & Allameh, A. (2003). Class-Pi of glutathione S-transferases. Iranian Journal of Biotechnology, 4(1), 1-16.
MLA
Somaieh Kazemnejad; Yusef Rasmi; Roya Sharifi; Abdolamir Allameh. "Class-Pi of glutathione S-transferases". Iranian Journal of Biotechnology, 4, 1, 2003, 1-16.
HARVARD
Kazemnejad, S., Rasmi, Y., Sharifi, R., Allameh, A. (2003). 'Class-Pi of glutathione S-transferases', Iranian Journal of Biotechnology, 4(1), pp. 1-16.
VANCOUVER
Kazemnejad, S., Rasmi, Y., Sharifi, R., Allameh, A. Class-Pi of glutathione S-transferases. Iranian Journal of Biotechnology, 2003; 4(1): 1-16.
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