Green Synthesis of Polylactic acid/Fe3 O4 @β-Cyclodextrin Nanofibrous Nanocomposite Loaded with Ferulago Angulata Extract as a Novel Nano-biosorbent: Evaluation of Diazinon Removal and Antibacterial Activity

Document Type : Research Paper


1 Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran

2 Department of Chemistry, Kerman branch, Islamic Azad University, Kerman, Iran


Background: Organophosphate pesticides are one of the most extensively applied insecticides in agriculture. These 
insecticides persist in the environs and thereby cause severe pollution problems. Iron oxide polymer nanocomposites are 
wastewater remediation agents synthesized by various methods. When compared to chemical processes, green synthesis 
using plant extract is thought to be more cost- and environmentally-friendly. 
Objectives: This study aimed to evaluate the green synthesis of Fe3
@β-Cyclodextrin (Fe3
@β-CD) nanoparticles using 
Ferulago angulata (F. angulata) methanol extract. These nanoparticles are loaded on polylactic acid (PLA) nanofibrous 
nanocomposite along with Ferulago angulata extract (2, 4, and, 6wt %) to produce PLA/Fe3
@β-CD/F. angulata extract 
nanofibrous nanocomposite as a new nano biosorbent. Furthermore, the antibacterial properties of this compound and its 
activity in diazinon removal have been evaluated.
Materials and Methods: Fe3
@β-CD nanoparticles synthesis was performed via co-precipitation method using 
O and FeCl2
O and β-cyclodextrin, and Ferulago angulata extract. Then polylactic acid/ Fe3
@β-CD / 
F. angulate.extract nanofibrous nanocomposite was prepared by the electrospinning method. Energy-dispersive X-ray 
spectroscopy (EDS), X-ray diffraction analysis (XRD), vibrating sample magnetometer (VSM), and Fourier transform 
infrared spectroscopy (FTIR) were used to analyze the structure of the nanocomposite. The antibacterial activity of this 
nanocomposite against several fish and human bacterial pathogens, as well as its effectiveness in diazinon elimination, 
have been evaluated in the sections that follow. 
Results: The nanocomposite structure demonstrated that Fe3
 nanoparticles were produced and put into the polylactic 
acid matrix with an average particle size of 40 nm. Furthermore, the results showed that this nanocomposite exhibited 
removal efficiency of diazinon over 80% after 120 minutes under pH=7 and 2.5 gr.L-1 nanocomposite concentration. 
Also, this structure showed above 70% antibacterial ability against Bacillus cereus, Staphylococcus epidermidis and 60% 
antibacterial ability against Streptococcus iniae and Yersinia ruckeri.
Conclusion: Fe3
 nanocomposite synthesis may be accomplished in a delicate and efficient manner by using Ferulago 
angulata to produce Fe3
@-CD nanoparticles. The stability of the nanoparticles was enhanced by combining Ferulago 
angulata extract with polylactic acid nanofibers to create an antibacterial homocomposition nanocomposite. This device 
may be used to remove and disinfect diazinon from aqueous media in an environmentally friendly manner.


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