The Gene Manipulation and Cellular Immunotherapy Combination in the Treatment of Cancer

Document Type : Review Paper


1 Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

3 Iran University of Medical Sciences, Tehran, Iran

4 Department of Medical Laboratory Sciences, Allied Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran

5 Department of Pathology, University of California, Los Angeles, USA

6 Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


Context: The immune system is directly linked to the tumors, from tumor formation to the tumor’s development and 
metastasis. So, the interest of scientists over the protective immunological mechanisms has increased and shown gifted 
strategy in cancer treatment. 
Evidence acquisition: Genetic engineering and cellular immunotherapy are two different advanced molecular mechanisms to modify the immune responses and genome. Gene manipulation is the bioengineering technology that allows vectors to transfer new genetic information into the target cells. Cellular immunotherapy is an excellent strategy that connects the body’s immune system to fight cancer. 
Results & Conclusions: This review described that combination of genetic engineering and cellular immunotherapy has 
brought the novel antitumor repressive molecules stopping the tumor tissue immune tolerance and significantly expanding  cancer therapy’s effectiveness. Usually, cell immunotherapy and genetic engineering are considered two independent  processes, and, in this review, we believe them in combinations. Here, we review these two novel approaches, and they  are both combinations in terms of technological advances and clinical experience.


Main Subjects