TY - JOUR ID - 143812 TI - The Gene Manipulation and Cellular Immunotherapy Combination in the Treatment of Cancer JO - Iranian Journal of Biotechnology JA - IJB LA - en SN - 1728-3043 AU - Khatami, Fatemeh AU - Aghamir, Zahra Sadat AU - Jahanshahi, Fatemeh AU - Feiz-Abadi, Seyed Ariana AU - Birang, Fatemeh AU - Khoshchehreh, Mahdi AU - Namazi Shabestari, Alireza AU - Aghamir, Seyed Mohammad Kazme AD - Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran AD - Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran AD - Iran University of Medical Sciences, Tehran, Iran AD - Department of Medical Laboratory Sciences, Allied Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Pathology, University of California, Los Angeles, USA AD - Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Y1 - 2022 PY - 2022 VL - 20 IS - 2 SP - 1 EP - 14 KW - Chimeric Antigen Receptor T cell KW - Engineered T cell receptor KW - Natural Killer Cell KW - Tumor-Infiltrating Lymphocyte DO - 10.30498/ijb.2022.294933.3094 N2 - Context: The immune system is directly linked to the tumors, from tumor formation to the tumor’s development and metastasis. So, the interest of scientists over the protective immunological mechanisms has increased and shown gifted strategy in cancer treatment. Evidence acquisition: Genetic engineering and cellular immunotherapy are two different advanced molecular mechanisms to modify the immune responses and genome. Gene manipulation is the bioengineering technology that allows vectors to transfer new genetic information into the target cells. Cellular immunotherapy is an excellent strategy that connects the body’s immune system to fight cancer. Results & Conclusions: This review described that combination of genetic engineering and cellular immunotherapy has brought the novel antitumor repressive molecules stopping the tumor tissue immune tolerance and significantly expanding  cancer therapy’s effectiveness. Usually, cell immunotherapy and genetic engineering are considered two independent  processes, and, in this review, we believe them in combinations. Here, we review these two novel approaches, and they  are both combinations in terms of technological advances and clinical experience. UR - https://www.ijbiotech.com/article_143812.html L1 - https://www.ijbiotech.com/article_143812_d95643bd395c9525ce972ed3805a6061.pdf ER -