%0 Journal Article %T Vacuolating Cytotoxin of Helicobacter pylori %J Iranian Journal of Biotechnology %I National Institute of Genetic Engineering and Biotechnology of Iran %Z 1728-3043 %A Talebkhan, Yeganeh %A Mohammadi, Marjan %D 2003 %\ 04/01/2003 %V 1 %N 2 %P 73-81 %! Vacuolating Cytotoxin of Helicobacter pylori %K Helicobacter pylori %K Vacuolating cytotoxin %K vacA %K virulence %K Pathogenesis %R %X Vacuolating cytotoxin (VacA) is one of the most important virulence factors of H. pylori (Hp), which isthe only toxic protein that is secreted from Hp cell into the culture supernatant. The effects of VacA oneukaryotic systems is the subject of many previous and on going research studies. Intracellular targetsfor this toxin include: late endosomal and lysosomal compartments, mitochondria, cell-cell junctions andphospholipid bilayers. Its effects on these targets include vacuolation of late endosomal and lysosomalcompartments, apoptosis and channel formation, which result in the increase of ion uptake speciallyanions. The aim of this review is to increase the perception on this toxin and its functions. %U https://www.ijbiotech.com/article_6891_8b91d7bd3cfc332ade762275b3525e6e.pdf