@article { author = {Hadavi, Valeh and Sanati, Mohammad H and Farhud, Daroush and Hushmand, Masoud and Hashemzadeh Chaleshtori, Morteza and Nabavi, Seyed Masoud and Younesian, Masoud and Seyedian, Maziar}, title = {Association of Apolipoprotein E Polymorphism with Susceptibility to Multiple Sclerosis}, journal = {Iranian Journal of Biotechnology}, volume = {2}, number = {1}, pages = {49-54}, year = {2004}, publisher = {National Institute of Genetic Engineering and Biotechnology of Iran}, issn = {1728-3043}, eissn = {2322-2921}, doi = {}, abstract = {Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complexetiology that includes a strong genetic component. The contribution of the major histocompatibility complex(MHC) has been established in numerous genetic linkage and association studies. In addition to theMHC, the chromosome 19q13 region surrounding the apolipoprotein E (APOE) gene has shown consistentevidence of involvement in MS. In a cross-sectional study, to show differences in APOE allele frequenciesin multiple sclerosis compared with controls, we genotyped polymorphisms in four alleles namely; ε2, ε3 ande4 alleles. This study was carried out on 81 patients with clinically definite MS and 93 asymptomatic,randomly selected elderly volunteers. A significant difference was observed in the distribution of e4 allelebetween patients with MS and controls (9.3% vs. 0.5%; χ2=15.2; df=2; p<0.001). This provides strong support for the association of MS with APOE ε4 allele.}, keywords = {Multiple Sclerosis,Apolipoprotein E,Polymorphism,Iran}, url = {https://www.ijbiotech.com/article_6922.html}, eprint = {https://www.ijbiotech.com/article_6922_a28d9461f240fdf81bf1cfca204259b0.pdf} }